2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W096153
    m-PEG3-phosphonic acid 96962-42-4
    m-PEG3-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG3-phosphonic acid
  • HY-140744
    Benzyl-PEG5-azide 86770-72-1
    Benzyl-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzyl-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Benzyl-PEG5-azide
  • HY-138346
    Benzyl-PEG4-Boc 2484091-04-3
    Benzyl-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG4-Boc
  • HY-138483
    THP-PEG9-OH 669556-83-6
    THP-PEG9-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG9-OH
  • HY-141305
    Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid 1446282-17-2
    Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Diethoxy-phosphorylethyl-PEG5-ethylphosphonic acid
  • HY-140003
    Tetraethyl butane-1,4-diylbis(phosphonate) 7203-67-0
    Tetraethyl butane-1,4-diylbis(phosphonate) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tetraethyl butane-1,4-diylbis(phosphonate)
  • HY-138418
    Azido-PEG7-CH2COOH 1446411-32-0
    Azido-PEG7-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-CH2COOH
  • HY-145255
    Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH
    Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
    Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH
  • HY-141282
    Methyltetrazine-PEG24-Boc
    Methyltetrazine-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG24-Boc
  • HY-140613
    Boc-PEG4-sulfone-PEG4-Boc
    Boc-PEG4-sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-PEG4-sulfone-PEG4-Boc
  • HY-141061
    N-PEG3-N'-(azide-PEG3)-Cy5 2226235-96-5
    N-PEG3-N'-(azide-PEG3)-Cy5 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-PEG3-N'-(azide-PEG3)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-PEG3-N'-(azide-PEG3)-Cy5
  • HY-140833
    m-PEG36-azide
    m-PEG36-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG36-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG36-azide
  • HY-140546
    N-(Azido-PEG3)-N-Fluorescein-PEG4-acid 2100306-72-5
    N-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-Fluorescein-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-Fluorescein-PEG4-acid
  • HY-140436
    t-Boc-Aminooxy-PEG7-bromide 2353410-15-6
    t-Boc-Aminooxy-PEG7-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    t-Boc-Aminooxy-PEG7-bromide
  • HY-132104
    THP-PEG12-alcohol
    THP-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG12-alcohol
  • HY-134744
    Boc-Pyrrolidine-PEG2-COOH
    Boc-Pyrrolidine-PEG2-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Pyrrolidine-PEG2-COOH
  • HY-134700
    DSPE-PEG14-COOH
    DSPE-PEG14-COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    DSPE-PEG14-COOH
  • HY-130880
    HS-PEG11-CH2CH2N3 2148986-08-5
    HS-PEG11-CH2CH2N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. HS-PEG11-CH2CH2N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    HS-PEG11-CH2CH2N3
  • HY-140791
    Azide-PEG9-amido-C16-Boc
    Azide-PEG9-amido-C16-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG9-amido-C16-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG9-amido-C16-Boc
  • HY-140771
    Azido-PEG1-PFP ester 1807505-32-3
    Azido-PEG1-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-PFP ester
PROTAC Linkers Isoform Comparison

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